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Innovations in Clinical Neuroscience. MDMA is listed as a Schedule 1 drug by the United States Drug Enforcement Agency, meaning that currently there are no accepted medical uses for MDMA in the United States, there is a lack of accepted safety for use under medical supervision, and there is a high potential for abuse.

International Journal of Psychiatry in Medicine. Pharmacology and abuse of cocaine, amphetamines, ecstasy and related designer drugs a comprehensive review on their mode of action, treatment of abuse and intoxication Online-Ausg.

Dordrecht: Springer Netherlands. Los Angeles Times. Retrieved 22 February Retrieved on 11 June Journal of Psychoactive Drugs.

Drug Enforcement Administration. October Retrieved 10 April Drugs, Inc. TV documentary. National Geographic Channel.

Emergency Nurse. Journal of Clinical Pharmacology. Sexually Transmitted Infections. Retrieved 14 May Dialogues in Clinical Neuroscience.

Life Sciences. In contrast, MDMA produces damage to serotonergic, but not dopaminergic axon terminals in the striatum, hippocampus, and prefrontal cortex Battaglia et al.

The damage associated with Meth and MDMA has been shown to persist for at least 2 years in rodents, non-human primates and humans Seiden et al. Given the dose-response relationship between MDMA exposure and SERT reductions and the statistically non-significant SERT binding differences for users with use levels similar to the majority of real-life users, it can be speculated that SERT levels may not be significantly affected for most recreational ecstasy users.

Health Technology Assessment. Bibcode : PLoSO.. Human Psychopharmacology. Frontiers in Pharmacology. Human biology 10th ed.

British Journal of Pharmacology. Drug and Chemical Toxicology. Toxicology in Vitro. In summary, MDMA is a moderate teratogen that could influence cardiac and neuronal differentiation in the ESC model and these results are in concordance with previous in vivo and in vitro models.

Neurotoxicology and Teratology. The Journal of Neuroscience. Clinical Textbook of Addictive Disorders. Guilford Publications. MDMA's addictive liability appears to be lower than that of other drugs of abuse It seems to present a smaller addiction potential than cocaine or methamphetamine.

Principles of addiction medicine 4th ed. Biological Chemistry. There are no known pharmacological treatments for MDMA addiction.

British Journal of Anaesthesia. Therapeutic Drug Monitoring. It is known that some recreational drugs e. Oxford American Handbook of Critical Care.

Oxford University Press. British Journal of Nursing. Clinical Journal of the American Society of Nephrology. Journal of Neurochemistry. University of Alberta.

Retrieved 15 May It enters neurons via carriage by the monoamine transporters. Once inside, MDMA inhibits the vesicular monoamine transporter, which results in increased concentrations of serotonin, norepinephrine, and dopamine into the cytoplasm, and induces their release by reversing their respective transporters through a process known as phosphorylation.

The subsequently observed regulatory effect of TAAR1 on dopaminergic systems has further strengthened this interest, given their well-documented involvement in reward circuitry.

European Journal of Pharmacology. Neurochemistry International. Canadian Medical Association Journal. Goldfrank's toxicologic emergencies 9th ed.

Neuroscience Letters. Molecular Pharmacology. Expert Review of Clinical Pharmacology. The Journal of Pharmacology and Experimental Therapeutics. British Journal of Clinical Pharmacology.

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Retrieved 1 December Retrieved on 12 August Plasma pharmacokinetics of 3,4-methylenedioxymethamphetamine after controlled oral administration to young adults.

Drug Monit. Die Pharmazie. Merck in Darmstadt 16 May Kaiserliches Patentamt. Retrieved 12 April Merck in Darmstadt 15 October History of MDMA".

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Nonmedical use and intoxication" PDF. The New York Times Company. Retrieved 27 August Retrieved 4 January Drug Abuse Information and Monitoring Project.

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The Psychopharmacology of Hallucinogens. New York: Pergamon Press. New York Times Magazine. Primetime Thursday Special edition.

ABC News. Archived from the original on 27 May In Doblin R ed. The Secret Chief Revealed 2nd ed. Retrieved 7 January Berkeley, CA: Ronin Publishing.

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